Mitochondrial and skeletal muscle health with advancing age
نویسندگان
چکیده
منابع مشابه
Molecular Mechanisms for Age-Associated Mitochondrial Deficiency in Skeletal Muscle
The abundance, morphology, and functional properties of mitochondria decay in skeletal muscle during the process of ageing. Although the precise mechanisms remain to be elucidated, these mechanisms include decreased mitochondrial DNA (mtDNA) repair and mitochondrial biogenesis. Mitochondria possess their own protection system to repair mtDNA damage, which leads to defects of mtDNA-encoded gene ...
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Wray DW, Nishiyama SK, Richardson RS. Role of 1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age. Am J Physiol Heart Circ Physiol 296: H497–H504, 2009. First published December 5, 2008; doi:10.1152/ajpheart.01016.2008.— 1-Adrenergic vasoconstriction during dynamic leg exercise is diminished in younger individuals, although the extent of this exercis...
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Mitochondria are the main source of cellular energy production and are dynamic organelles that undergo biogenesis, remodeling, and degradation. Mitochondrial dysfunction is observed in a number of disease states including acute and chronic central or peripheral nervous system injury by traumatic brain injury, spinal cord injury (SCI), and neurodegenerative disease as well as in metabolic distur...
متن کاملMitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle.
Mitochondrial health is critical to physiological function, particularly in tissues with high ATP turnover, such as striated muscle. It has been postulated that derangements in skeletal muscle mitochondrial function contribute to impaired physical function in older adults. Here, we determined mitochondrial respiratory capacity and coupling control in skeletal muscle biopsies obtained from young...
متن کاملSkeletal muscle mitochondrial dysfunction & diabetes.
Skeletal muscle insulin resistance is a key contributor to the pathophysiology of type 2 diabetes. Recent studies have shown that insulin resistance in a variety of conditions including type 2 diabetes, ageing and in offspring of type 2 diabetes is associated with muscle mitochondrial dysfunction. The important question is whether insulin resistance results from muscle mitochondrial dysfunction...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2013
ISSN: 0303-7207
DOI: 10.1016/j.mce.2013.05.008